Angiotensin II receptor pharmacology and AT1-receptor blockers
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چکیده
منابع مشابه
Angiotensin II receptor blockers.
BUMC PROCEEDINGS 2003;16:123–126 The angiotensin II receptor blockers (ARBs) represent a newer class of antihypertensive agents. Their mechanism of action differs from that of the angiotensin-converting enzyme (ACE) inhibitors, which also affect the renin-angiotensin system. The ARBs were developed to overcome several of the deficiencies of ACE inhibitors: competitive inhibition of ACE results ...
متن کاملAT1-receptor blockers
finding of elevated leptin levels in cardiac failure patients stage NYHA II or III is supported by Filippatos et al. and others. From their data, however, it appears that leptin levels tend to decrease in cachectic patients with more advanced stages of the disease, which has only recently been confirmed by others. This does not necessarily contradict our observations. The patients reported in o...
متن کاملAngiotensin II receptor blockers and nephropathy trials.
This is the first of a series of reports on the American Diabetes Association (ADA) 61st Scientific Sessions held in Philadelphia in June 2001. It covers topics related to angiotensin II receptor blockers (ARBs) and nephropathy. At a symposium at the 61st Scientific Sessions of the ADA in June 2001, the results of three recent diabetic nephropathy trials with angiotensin II subtype 1 receptor a...
متن کاملAngiotensin II Receptor Blockers and Cancer Risk
Angiotensin II receptor blockers (ARB) are widely used drugs that are proven to reduce cardiovascular disease events; however, several recent meta-analyses yielded conflicting conclusions regarding the relationship between ARB and cancer incidence, especially when ARB are combined with angiotensin-converting enzyme inhibitors (ACEI).We investigated the risk of cancer associated with ARB at diff...
متن کاملAngiotensin II receptor subtypes AT1 and AT2 are down-regulated by angiotensin II through AT1 receptor by different mechanisms.
The regulatory effects of angiotensin II (AngII) on its receptor subtypes, AT1 and AT2, were studied using cultured bovine adrenal cells (BAC), which express both receptor subtypes, and PC12W and R3T3 cells, which express only AT2 receptors. In BAC, AngII caused a decrease in AT1- and AT2-binding sites and their corresponding messenger RNAs (mRNAs), but with different kinetics. AT1-binding site...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 1999
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1000744